Casandra
Casandra Test Code QD97355Version 1 (DRAFT)
Performing Lab
FISH, MET Amplification
Also known as: Renal Cancer, Tyrosine Kinase, c-MET, NSCLC, Mesencymal Epithelial Transition Factor
Clinical Use
Order TestUse
The proto‑oncogene MET (c‑MET) encodes a hepatocyte growth factor receptor with tyrosine‑kinase activity. Overexpression or amplification of MET has been observed in a variety of neoplasms, including kidney, lung, head and neck, ovary, breast, thyroid, brain, stomach, pancreas, and colon. MET gene amplification, detected by FISH, has been associated with unfavorable prognosis in non‑small cell lung cancer (NSCLC) and resistance to EGFR inhibitors.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number RegionCopy Number • Categorical (e.g., Positive / Negative / Indeterminate)
Unknown CNV
Copy Number RegionCopy Number • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided