Use

This test employs a two-step serologic approach: an FDA‑cleared HSV‑2 IgG assay on the Diasorin Liaison XL platform, reflexing to an HSV‑2 IgG inhibition immunoassay for specimens with index values between 1.10 and 6.00 to reduce false positives in low-positive screens. It is used to detect HSV‑2 type‑specific IgG antibodies, though serologic testing is not the preferred diagnostic method for genital herpes—NAAT or culture of lesions is preferred; serology may be useful in recurrent atypical genital symptoms negative by PCR, clinical diagnosis without lab confirmation, or for partners at higher risk or with history of genital herpes. A negative result does not definitively rule out infection, particularly in early infection stages or rare glycoprotein G deficient isolates. (Reflex confirmatory testing improves specificity.)