Mutated Citrullinated Vimentin (MCV) Antibody
Also known as: anti-MCV, RA, Rheumatoid arthritis
Use
Anti‑mutated citrullinated vimentin (MCV) antibody is a specific anti-citrullinated protein antibody used as a second‑line marker of rheumatoid arthritis (RA), alongside rheumatoid factor and anti‑cyclic citrullinated peptide (CCP). Compared to CCP, MCV antibody is slightly less specific but offers higher sensitivity, and when used together with CCP, can increase RA diagnostic sensitivity by approximately 5–10%. Additionally, MCV antibody positivity is associated with more severe disease and greater radiographic progression, further supporting its clinical utility in assessing RA prognosis.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Immunoassay (ELISA)
Biomarkers
Mutated Citrullinated Vimentin (MCV) Antibody
Protein
LOINC Codes
- 54022‑9
- 54022‑9
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
red‑top tube or serum separator tube
Collection Instructions
Draw whole blood using red‑top tube or serum separator tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 6 months |
Other tests from different labs that may be relevant