Cortisol by LC-MS/MS, Salivary
Also known as: CORT S TMS
Use
This test is used to rule out Cushing syndrome or to screen for thymic and bronchial carcinoid tumors. It is a salivary cortisol test which is particularly relevant in the assessment of adrenal hyperfunction, particularly for diagnostics relating to Cushing Syndrome where salivary cortisol measurements can provide an indication of circadian rhythm and adrenal output.
Special Instructions
Recommended collection time for the specimen is generally between 11 p.m. and 1 a.m., although your healthcare provider may require different or additional collection times. It is important to clearly label each collection tube with the correct date and time. Avoid eating, consuming alcohol, using toothpaste, mouthwash, or lip products prior to collection to prevent contamination which could result in falsely elevated cortisol levels.
Limitations
Specimens not collected using the Salivette collection device are unacceptable. During collection, contamination with exogenous cortisol sources or substances like blood, food particles, or cellular debris must be avoided as they may interfere with the test results. It's important to follow proper collection and storage protocols to ensure the stability and integrity of the specimen for accurate analysis.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 2142-8
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Saliva
Volume
1 mL or more
Minimum Volume
Not provided
Container
Salivette collection device (ARUP Supply #52056)
Collection Instructions
Collect saliva using Salivette collection device following ARUP instructions. Swab must be completely saturated. Avoid eating, drinking, and using oral products prior to collection.
Patient Preparation
Do not eat for 60 minutes prior to collecting specimen. Avoid alcohol for 12 hours before collection. Avoid brushing teeth or using mouthwash immediately before collection.
Storage Instructions
Store and transport refrigerated or frozen.
Causes for Rejection
Specimens not collected using Salivette, or visibly contaminated with blood, cellular debris, food particles, or mucus.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 3 weeks |
| Frozen | 6 months |