Epithelial-Related Antigen, MOC-31 by Immunohistochemistry
Also known as: ERA IHC
Use
Immunohistochemical staining for the epithelial-related antigen MOC‑31 is used for epithelial differentiation, particularly to help distinguish adenocarcinomas from mesotheliomas. The stain reacts with a membrane glycoprotein expressed in epithelial cells, aiding in pathology interpretation by identifying adenocarcinoma cells in tissue or cell block preparations.
Special Instructions
Not provided.
Limitations
Specimens submitted with non‑representative tissue or depleted tissue are unacceptable. Slides should not be oven‑baked. Frozen specimens are unacceptable. The performance is specific to formalin‑fixed, paraffin‑embedded tissue or cell block preparations.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6 - Tissue block ID Spec
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Container
tissue block or unstained slides (minimum 2 slides) in tissue transport kit (ARUP supply #47808)
Collection Instructions
Collect tissue or cells. Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen; cell blocks for cells. Transport as tissue block or 5 unstained (3‑ to 5‑micron) positively charged slides in ARUP tissue transport kit; if sending precut slides, do not oven bake.
Storage Instructions
Room temperature or refrigerated. Ship in cooled container during summer months.
Causes for Rejection
Non‑representative tissue type; depleted specimens; frozen specimens; oven‑baked slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant