INSM1 by Immunohistochemistry
Also known as: INSM1 IHC
Use
INSM1 by Immunohistochemistry is a technical immunohistochemical stain service used to detect insulinoma‑associated protein 1 (INSM1), a sensitive and specific marker of neuroendocrine differentiation, particularly for neuroendocrine and neuroepithelial neoplasms. The stain is performed on formalin‑fixed, paraffin‑embedded tissue or cell block specimens and is returned to the submitting provider for interpretation by the pathologist. It serves as a nuclear marker useful to support the diagnosis of neuroendocrine tumors.
Special Instructions
Not provided.
Limitations
Specimens must contain representative tissue; depleted specimens or non‑representative tissue types are unacceptable. Frozen specimens are unacceptable. While the stain is returned to the submitting provider, interpretation is not included and must be performed separately by a pathologist. Performance limitations beyond technical staining are not described.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
INSM1
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
Not provided
Minimum Volume
5 unstained (3‑ to 5‑micron thick sections), min: 2 slides
Collection Instructions
Transport tissue block or 5 unstained (3‑ to 5‑micron thick sections), positively charged slides in a tissue transport kit (recommended but not required). ARUP supply #47808 available online through ARUP Connect or contact ARUP Client Services.
Storage Instructions
Room temperature; also acceptable refrigerated; ship in cooled container during summer months.
Causes for Rejection
Non‑representative tissue type; depleted specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant