Treponema pallidum (VDRL), Serum with Reflex to Titer
Also known as: VDRL SERU
Use
The test is used as an initial screening for syphilis under the traditional algorithm and may also be used to confirm a reactive treponemal test in the reverse algorithm. It is a suitable test for monitoring treatment response in established syphilis cases. The VDRL test, while a common screening tool, is less sensitive than the RPR test, thus it may miss some infections.
Special Instructions
If the VDRL test is reactive, a titer will be added to determine the concentration of antibodies. This will incur additional charges. It is important to transfer serum from cells as soon as possible or within 2 hours of collection for optimal results.
Limitations
The VDRL test is less sensitive than the Rapid Plasma Reagin (RPR) test when used as a screening method for syphilis. This reduced sensitivity can lead to missed infections if this is the sole testing method. Additionally, the test is reactive to conditions causing similar non-specific antibodies, potentially causing false positives. Performance may also vary due to specimen handling, so conditions like contamination, hemolysis, or severe lipemia can affect results.
FDA ApprovedNew York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 5292-8
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Causes for Rejection
CSF or other body fluids. Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |