Oncology FISH Analysis - TEL/AMLI: t(12;21) [ALL]

Casandra

Casandra Test Code BA32560Version 1 (DRAFT)

Performing Lab

Lab Baylor GeneticsLab Test ID 8755CPT Codes 88237, 88271, 88275, 88291

Oncology FISH Analysis - TEL/AMLI: t(12;21) [ALL]

Clinical Use

Use

Oncology FISH Analysis - TEL/AMLI: t(12;21) is a Fluorescence In Situ Hybridization (FISH) test designed to detect translocation between 12p13 and 21q22, which fuses the N-terminus of TEL with the AML1 gene. The TEL/AML1 fusion is associated with acute lymphoblastic leukemia (ALL). This translocation is noted in approximately 25% of B-cell childhood ALL cases and 5% of adult ALL cases, indicating a favorable prognosis. Results must be interpreted in the context of clinical and pathological data, and the test should not be relied upon alone for diagnosis.

Special Instructions

This assay is particularly useful for patients who either exhibit clinical signs of acute lymphoblastic leukemia (ALL) or where prior cytogenetic testing has failed. Additionally, it serves a vital role in monitoring treatment responses and identifying prognostic anomalies in diagnosed patients. Shipping conditions are strict, and specimens must be sent in insulated containers to maintain ambient temperature, arriving within a specified timeframe for optimal results.

Limitations

This FISH assay only identifies the specific translocation of the TEL gene on 12p13 and AML1 gene on 21q22.12 and cannot determine translocations involving other partner chromosomes. Therefore, other potential genetic abnormalities may not be detected.

Test Details