Adult Acute Lymphoblastic Leukemia (ALL) Profile, FISH
Also known as: Acute Lymphoblastic Leukemia; Leukemia/Lymphoma-specific FISH
Use
Diagnostic and prognostic test for acute lymphoblastic leukemia in the pediatric population; detection rate is improved from 50% with a chromosome study to 90% with fluorescence in situ hybridization (FISH)
Special Instructions
When ordering this test, it is essential to include the patient's pertinent clinical diagnosis and provide any previous cytogenetic studies. This information is critical for the comprehensive analysis and accurate interpretation of the FISH results. Proper coordination with ordering forms is recommended to ensure accurate processing and reporting of results.
Limitations
The FISH analysis conducted for this test is limited to detecting abnormalities identified by the specific probes included. It should be interpreted as part of a comprehensive cytogenetic and hematologic evaluation, as it does not provide information beyond the defined target areas. Moreover, the test is not FDA cleared or approved, reflecting that such regulatory endorsements were deemed unnecessary for its diagnostic purposes by the responsible authorities.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 511077
- 31208-2
- 62361-1
- 62360-3
- 62356-1
- 62365-2
- 48672-0
- 11502-2
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL blood (pediatric)
Minimum Volume
5 mL blood (pediatric)
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). Adjust tube size to sample volume to avoid heparin toxicity.
Collection Instructions
Transport to the testing laboratory at room temperature, use of a cool pack or a LabCorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Storage Instructions
Maintain the specimen at either room temperature or refrigerate. Do not freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis